Effects of In vitro hemodilution, hypothermia and rFVIIa addition on coagulation in human blood

International Journal of Burns and Trauma

Michael A Dubick¹  Angel V Delgado¹  Igor Kremenevskiy¹  Bijan S Kheirabaldi¹  Chriselda G Fedyk¹  Daniel N Darlington¹  Anthony E Pusateri¹  Michael R Scherer¹ 

关键词: TEG;    thrombin generation;    PT;    aPTT;   

DOI  :  

学科分类：外科医学

来源: e-Century Publishing Corporation

【 摘 要 】

Coagulopathy can occur after hemorrhage, trauma and resuscitation, and has been associated with dilution of coagulation factors and hypothermia. Recombinant activated Factor VII (rFVIIa) has been used, often as a last resort, to improve hemostasis in trauma/hemorrhage patients with coagulopathy. The aim of this study was to further characterize the effects of rFVIIa on various coagulation parameters and the influence of temperature and hemodilution.

【 授权许可】

Unknown