Comorbid Heart Failure and Renal Impairment: Epidemiology and Management

Cardiorenal Medicine

Nagesh S. Anavekar¹  Pupalan Iyngkaran¹  Claudio Ronco¹  Merlin Thomas¹  William Majoni¹ 

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关键词: Heart failure;    Renal failure;    Cardiorenal syndrome;   

DOI  :  10.1159/000342487

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Heart failure mortality is significantly increased in patients with baseline renal impairment and those with underlying heart failure who subsequently develop renal dysfunction. This accelerated progression occurs independent of the cause or grade of renal dysfunction and baseline risk factors. Recent large prospective databases have highlighted the depth of the current problem, while longitudinal population studies support an increasing disease burden. We have extensively reviewed the epidemiological and therapeutic data among these patients. The evidence points to a progression of heart failure early in renal impairment, even in the albuminuric stage. The data also support poor prescription of prognostic therapies. As renal function is the most important prognostic factor in heart failure, it is important to establish the current understanding of the disease burden and the therapeutic implications.

【 授权许可】

Unknown