Echocardiographic characteristics of patients with acute heart failure requiring tolvaptan: a retrospective study

Cardiovascular Ultrasound

Research

Manabu Horii¹  Shinichi Fujimoto²  Kenji Onoue³  Yukiji Takeda³  Rika Kawakami³  Satoshi Okayama³  Shiro Uemura³  Yoshihiko Saito³  Yasuki Nakada³  Tomoya Ueda³  Tomoya Nakano³ 

[1] Department of Cardiovascular Internal Medicine, Nara City Hospital, Nara, Japan;Education Development Center, Nara Medical University, Nara, Japan;First Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, 634-8522, Nara, Kashihara, Japan;

关键词: Diuretics;    Cardiorenal syndrome;    Renal dysfunction;    Renal failure;    Tolvaptan;    Left atrium;    Inferior vena cava;    Tricuspid regurgitation;   

DOI  :  10.1186/s12947-015-0022-7

 received in 2015-01-08, accepted in 2015-06-01,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundNo study has investigated the admission echocardiographic characteristics of acute heart failure (AHF) patients who are resistant to conventional diuretics and require tolvaptan.MethodsWe retrospectively analyzed the echocardiographic characteristics of AHF patients who were resistant to conventional diuretics and took tolvaptan (tolvaptan group: 26 patients), and compared them to those who were sensitive to conventional diuretics (conventional group: 180 patients).ResultsThe tolvaptan group had a higher left atrial volume index (96.0 ± 85.0 mL/m2 vs. 45.8 ± 25.9 mL/m2, p < 0.0001), maximum inferior vena cava diameter (20.7 ± 6.9 mm vs. 18.1 ± 4.2 mm, p < 0.01), and higher tricuspid regurgitation grade (1.1 ± 0.8 vs. 0.8 ± 0.6, p < 0.05) than the conventional group. However, the left ventricular ejection fraction and end diastolic diameter were similar between the groups. Responders of tolvaptan had no significant echocardiographic differences compared to the non-responders.ConclusionsThe admission echocardiographic characteristics of AHF patients requiring tolvaptan included a larger left atrium, inferior vena cava, and more severe tricuspid regurgitation. Echocardiography may provide useful information for the early and appropriate initiation of tolvaptan.

【 授权许可】

Unknown   
© Nakada et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.