Association Between IFN-? Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

Kidney and Blood Pressure Research

Wei L.¹  Liu X.²  Niu D.⁴  Yao G.¹  Yu Q.⁵  Jin T.³  Fu R.¹  Gao J.¹  Wang L.¹  Wang M.² 

[1] Department of Nephrology, Xi’an, China$$;Department of Oncology, Second Affiliated Hospital, Xi’an, China$$;National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi’an, China$$;Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China$$;Department of Pathology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China$$

关键词: IgA nephropathy;    IFN-?;    Risk;    Case-control study;   

DOI  :  10.1159/000473889

来源: S Karger AG

【 摘 要 】

Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.

【 授权许可】

Unknown