Hypovitaminosis D increases TB co-infection risk on HIV patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Gayatri, Y.A.A.A.^1 ; Sukmawati, D.D.^1 ; Utama, S.M.^1 ; Somia, I.K.A.^1 ; Merati, T.P.^1

Tropical and Infectious Disease Division, Internal Medicine Department, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia^1

关键词: Case-control study;    Cell-mediated immune;    Chemiluminescent immunoassays;    Co-infections;    Inter quartile ranges;    Multivariate logistic regressions;    Mycobacterium tuberculosis;    Serum concentration;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012097/pdf
DOI  :  10.1088/1755-1315/125/1/012097

来源: IOP

【 摘 要 】

Tuberculosis is causes of mortality and morbidity in patients with HIV. Hypovitaminosis D, a defective cell-mediated immune response to Mycobacterium tuberculosis infection has been extensively described in HIV patients, but studies assessing the role of vitamin D in TB-HIV co-infection are lacking. We, therefore, conducted a 1:1 pair- matched case-control study to verify hypovitaminosis D possible risk factor of TB- HIV co- infection. Consecutive HIV patients starting ARV and sex, age and CD4 cell count matched were by recruiting. Tuberculosis has confirmed by thepresence of acid-fast bacilli in sputum or mycobacterium detected in specimens culture/Gene Xpert/PCR.Vitamin D levels were by measuring direct chemiluminescent immunoassay on a LIAISON® 25OH analyzer. The study comprised 25 cases and 25 controls, median (interquartile range) 25(OH)D3 serum concentration were 19.80 (12.15-27.45) ng/mL in cases and 33.30 (27.2-39.4) ng/mL in controls (P