FEBS Letters | |
STAM/EAST/Hbp adapter proteins – integrators of signalling pathways | |
Lehto, Veli-Pekka2  Lohi, Olli1  | |
[1] Department of Pediatrics, University of Tampere, PL 2000, Tampere FIN-33521, Finland;Department of Pathology, University of Oulu, PL 5000, Oulu FIN-90014, Finland | |
关键词: Adapter; EAST; Endocytosis; Hbp; Receptor; STAM; | |
DOI : 10.1016/S0014-5793(01)03079-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
STAM/EAST/Hbp family of proteins consists of eight members well conserved from yeast to mammals. The basic domain architecture is comprised of an N-terminal Vps27, Hrs and STAM homology domain, a ubiquitin-interacting motif and a central Src homology-3 domain. Vertebrate members also carry an immunoreceptor tyrosine-based activation motif. STAM/EAST/Hbp proteins become tyrosine-phosphorylated by a variety of cytokines and growth factors. STAM 1 and STAM 2A are involved in cytokine-mediated signalling for DNA synthesis and c-myc induction. EAST and STAM 2A/Hbp play a role in receptor-mediated endo- and exocytosis and probably also in the regulation of actin cytoskeleton. Knockout experiments implicate a role for STAM 1 in neural cell survival. A picture is emerging of STAM/EAST/Hbp proteins acting as integrators of thus far mechanistically disparate cellular signalling events.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020311176ZK.pdf | 132KB | download |