STAM/EAST/Hbp adapter proteins – integrators of signalling pathways

FEBS Letters

Lehto, Veli-Pekka²  Lohi, Olli¹ 

[1] Department of Pediatrics, University of Tampere, PL 2000, Tampere FIN-33521, Finland;Department of Pathology, University of Oulu, PL 5000, Oulu FIN-90014, Finland

关键词: Adapter;    EAST;    Endocytosis;    Hbp;    Receptor;    STAM;   

DOI  :  10.1016/S0014-5793(01)03079-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

STAM/EAST/Hbp family of proteins consists of eight members well conserved from yeast to mammals. The basic domain architecture is comprised of an N-terminal Vps27, Hrs and STAM homology domain, a ubiquitin-interacting motif and a central Src homology-3 domain. Vertebrate members also carry an immunoreceptor tyrosine-based activation motif. STAM/EAST/Hbp proteins become tyrosine-phosphorylated by a variety of cytokines and growth factors. STAM 1 and STAM 2A are involved in cytokine-mediated signalling for DNA synthesis and c-myc induction. EAST and STAM 2A/Hbp play a role in receptor-mediated endo- and exocytosis and probably also in the regulation of actin cytoskeleton. Knockout experiments implicate a role for STAM 1 in neural cell survival. A picture is emerging of STAM/EAST/Hbp proteins acting as integrators of thus far mechanistically disparate cellular signalling events.

【 授权许可】

Unknown