Src phosphorylates EAST, a novel EGF receptor‐associated protein

FEBS Letters

Lehto, Veli-Pekka¹  Lohi, Olli¹ 

[1] Department of Pathology, University of Oulu, Kajaanintie 52D, FIN-90220 Oulu, Finland

关键词: EAST;    Epidermal growth factor receptor;    Endocytosis;    Phosphorylation;    Src;   

DOI  :  10.1016/S0014-5793(98)00874-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have recently found and characterized EAST, a novel EGF receptor-associated protein with SH3 and TAM domains. In this study we show that EAST becomes phosphorylated by Src kinase. This, in conjunction with our earlier observations on the close association between EAST and the endocytic machinery, suggests that EAST could be involved in Src-dependent effects on EGF receptor endocytosis.

【 授权许可】

Unknown