Markers of the Low Dose Radiation Response

Dynan, William S.

United States. Department of Energy.

关键词: Repair;    Antibodies;    59 Basic Biological Sciences;    Proteins;    Phosphorylation;   

DOI  :  10.2172/833471
RP-ID  :  EMSP-69909--2000
RP-ID  :  FG07-99ER62875
RP-ID  :  833471

美国|英语

来源: UNT Digital Library

【 摘 要 】

The development of tools for in situ visualization of DSB repair complexes. These tools will include fluorescently tagged repair proteins that can be used to visualize repair complex assembly in living cells. They will also include recombinant single-chain antibodies that will be used to detect changes in the conformation and phosphorylation state of DSB repair proteins that accompany the assembly of the repair complex.