Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function

Toxins

关键词: SPATE;    autotransporters;    pathogenic E. coli;    Shigella;    EspP;    Pet;    EspC;    Sat;    Vat;    Hbp;    EpeA;    Pic;    SepA;    SigA;    Tsh;   

DOI  :  10.3390/toxins2061179

来源: mdpi

【 摘 要 】

Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland