Biogenesis of transport intermediates in the endocytic pathway

FEBS Letters

Gruenberg, Jean¹  Gu, Feng¹ 

[1] Department of Biochemistry, Sciences II, University of Geneva, 1211 Geneva 4, Switzerland

关键词: Adapter;    COP protein;    Sorting;    Endosome;    Multivesicular body;   

DOI  :  10.1016/S0014-5793(99)00561-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is accumulating that membrane traffic between organelles can be achieved by different types of intermediates. Small (<100 nm) and short-lived vesicles mediate transport from the plasma membrane or the trans-Golgi network to endosomes, and formation of these vesicles depends on specific adapter complexes. In contrast, transport from early to late endosomes is achieved by relatively large (∼0.5 μm), long-lived and multivesicular intermediates, and their biogenesis depends on endosomal COP-I proteins. Here, we review recent work on the formation of these different transport intermediates, and we discuss, in particular, coat proteins, sorting signals contained in cargo molecules and the emerging role of lipid in vesicle biogenesis.

【 授权许可】

Unknown