Carotenoids are degraded by free radicals but do not affect lipid peroxidation in unilamellar liposomes under different oxygen tensions

FEBS Letters

Chen, Gang¹  Djuric, Zora¹ 

[1] Barbara Ann Karmanos Cancer Institute, 110 East Warren Ave., Detroit, MI 48201, USA

关键词: Carotenoid;    Liposome;    Lipid peroxidation;    Free radical;    ANOVA;    analysis of variance;    AAPH;    2;    2′-azobis(2-amidinopropane) dihydrochloride;    CD;    conjugated dienes;    HETE;    hydroxy-eicosateraenoic acid;    TBARS;    thiobarbituric acid-reactive substance;   

DOI  :  10.1016/S0014-5793(01)02671-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has been questioned whether carotenoids can act as antioxidants in biological membranes. Biological membranes can be modeled for studies of lipid peroxidation using unilamellar liposomes. Both carotenoid depletion and lipid peroxidation were increased with increasing oxygen tension in unilamellar liposomes. Carotenoids in such liposomes were found to be very sensitive to degradation by free radicals generated from iron and 2,2′-azobis(2-amidinopropane) dihydrochloride, but they were not protective against lipid peroxidation. Lycopene and β-carotene were more sensitive to free radical attack than lutein, zeaxanthin, and β-cryptoxanthin.

【 授权许可】

Unknown