Antioxidant role of melatonin in lipid peroxidation of human LDL

FEBS Letters

Esterbauer, Hermann²  Hayn, Marianne²  Liebmann, Peter¹  Schauenstein, Konrad¹  Abuja, Peter M.² 

[1] Institute of Experimental Pathology, University of Graz, Mozartgasse 14, A-8010 Graz, Austria;Institute of Biochemistry, University of Graz, Schubertstraße 1, A-8010 Graz, Austria

关键词: Low-density lipoprotein (LDL);    Antioxidant;    Lipid peroxidation;    Melatonin;    Free radical;    LDL;    low-density lipoprotein;    AAPH;    (2;    2′-azobis(amidinopropane hydrochloride));    BCSA;    bathocuproine disulfonic acid;    EDTA;    ethylenediaminetetraacetic acid;    PBS;    phosphate buffered saline;    CD;    conjugated dienes;    DPPH;    1;    1-diphenyl-2-picrylhydrazyl;   

DOI  :  10.1016/S0014-5793(97)00918-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is concluded that melatonin is not incorporated into LDL in sufficient concentrations to prevent lipid peroxidation effectively. When melatonin is present in the incubation medium during oxidation, a partitioning equilibrium between aqueous and lipid phase is established. Only under these conditions can melatonin act as a chain breaking antioxidant. The concentrations required, however, are far beyond those found in human plasma. Therefore, the data in this study do not support a direct physiological relevance of melatonin as an antioxidant in lipid peroxidation processes.

【 授权许可】

Unknown