期刊论文详细信息
FEBS Letters | |
Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4‐hydroxy‐2‐nonenal | |
Cuadros, R.2  Perry, G.1  Pérez, M.2  Smith, M.A.1  Avila, J.2  | |
[1] Department of Pathology, Case Western Reserve University, Cleveland, OH, USA;Centro de Biologı́a Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, 28049 Madrid, Spain | |
关键词: Tau assembly; Phosphorylation; 4-Hydroxy-2-nonenal; Lipid peroxidation; | |
DOI : 10.1016/S0014-5793(00)02323-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A correlation between hyperphosphorylation of tau protein and its aberrant assembly into paired helical filaments has lead to suggestions that phosphorylation controls assembly, but lacked a mechanistic basic. In this work, we have found that phosphorylated, but not native, tau protein is able to form polymers after the reaction with 4-hydroxy-2-nonenal, a highly toxic product of lipid peroxidation. Phosphorylation of tau by both proline or non-proline directed kinases, was able to assemble it into polymers.
【 授权许可】
Unknown
【 预 览 】
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RO201912020310067ZK.pdf | 214KB | download |