Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4‐hydroxy‐2‐nonenal

FEBS Letters

Cuadros, R.²  Perry, G.¹  Pérez, M.²  Smith, M.A.¹  Avila, J.² 

[1] Department of Pathology, Case Western Reserve University, Cleveland, OH, USA;Centro de Biologı́a Molecular ‘Severo Ochoa’ (CSIC-UAM), Universidad Autónoma de Madrid, 28049 Madrid, Spain

关键词: Tau assembly;    Phosphorylation;    4-Hydroxy-2-nonenal;    Lipid peroxidation;   

DOI  :  10.1016/S0014-5793(00)02323-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A correlation between hyperphosphorylation of tau protein and its aberrant assembly into paired helical filaments has lead to suggestions that phosphorylation controls assembly, but lacked a mechanistic basic. In this work, we have found that phosphorylated, but not native, tau protein is able to form polymers after the reaction with 4-hydroxy-2-nonenal, a highly toxic product of lipid peroxidation. Phosphorylation of tau by both proline or non-proline directed kinases, was able to assemble it into polymers.

【 授权许可】

Unknown