Tau aggregation into fibrillar polymers: taupathies

FEBS Letters

Avila, Jesús¹ 

[1] Centro de Biologı́a Molecular ‘Severo Ochoa’ (UAM-CSIC), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain

关键词: Tau protein;    Assembly;    Neurodegeneration;    Alzheimer's disease;   

DOI  :  10.1016/S0014-5793(00)01676-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Different neurological disorders, known as taupathies have been recently described. In these disorders it has been suggested that modifications in the microtubule-associated protein tau could cause neural degeneration in specific regions. Although these regions are different in the different taupathies, some common features appear to occur in all of them: abnormal hyperphosphorylation of tau and aberrant tau aggregation. These two features are commented upon in this review.

【 授权许可】

Unknown