Conjugated linoleic acid induces lipid peroxidation in humans

FEBS Letters

Basu, Samar¹  Smedman, Annika¹  Vessby, Bengt¹ 

[1] Section of Geriatrics/Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Box 609, SE-751 25 Uppsala, Sweden

关键词: Conjugated linoleic acid;    Prostaglandin;    Isoprostane;    Lipid peroxidation;    Human;    COX;    cyclooxygenase;    PG;    prostaglandin;    8-iso-PGF2α;    8-iso-prostaglandin F2α;    15-keto-dihydro-PGF2α/15-K-DH-PGF2α;    15-keto-13;    14-dihydro-prostaglandin F2α;    PGF2α;    prostaglandin F2α;    RIA;    radioimmunoassay;    CLA;    conjugated linoleic acid;    MDA;    malondialdehyde;    HPLC;    high pressure liquid chromatography;   

DOI  :  10.1016/S0014-5793(00)01193-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Conjugated linoleic acid (CLA) is shown to have chemoprotective properties in various experimental cancer models. CLA is easily oxidised and it has been suggested that an increased lipid oxidation may contribute to the antitumorigenic effects. This report investigates the urinary levels of 8-iso-PGF_2α, a major isoprostane and 15-keto-dihydro-PGF_2α, a major metabolite of PGF_2α, as indicators of non-enzymatic and enzymatic lipid peroxidation after dietary supplementation of CLA in healthy human subjects for 3 months. A significant increase of both 8-iso-PGF_2α and 15-keto-dihydro-PGF_2α in urine was observed after 3 months of daily CLA intake (4.2 g/day) as compared to the control group (P<0.0001). Conjugated linoleic acid had no effect on the serum α-tocopherol levels. However, γ-tocopherol levels in the serum increased significantly (P=0.015) in the CLA-treated group. Thus, CLA may induce both non-enzymatic and enzymatic lipid peroxidation in vivo. Further studies of the mechanism behind, and the possible consequences of, the increased lipid peroxidation after CLA supplementation are urgently needed.

【 授权许可】

Unknown