Intracellular free calcium concentration in human taste bud cells increases in response to taste stimuli

FEBS Letters

Mizuno, Akio⁴  Miyazaki, Toshihiro³  Fujiyama, Rie²  Miyamoto, Takenori²  Okada, Yukio²  Sato, Toshihide²  Inokuchi, Tsugio¹ 

[1] The Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan;Department of Oral Physiology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan;Department of Oral Histology, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan;The First Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan

关键词: Taste;    Human fungiform papilla;    Intracellular calcium;    Fura-2;   

DOI  :  10.1016/S0014-5793(98)00949-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We examined changes of intracellular free calcium concentration [Ca²⁺]_i elicited by taste stimuli of sucrose, denatonium and NaCl in the taste buds of seven human fungiform papillae. In one taste bud we observed an increase in [Ca²⁺]_i induced by only NaCl. In another bud an increase of [Ca²⁺]_i in response to both NaCl and sucrose was found. The Ca²⁺ responses to NaCl and sucrose occurred in differential areas within the one taste bud. In the other five fungiform papillae [Ca²⁺]_i was not changed by the taste stimuli. These results suggest that an increase of [Ca²⁺]_i participates in taste transduction mechanisms for sucrose and NaCl, and that taste cells in one taste bud may respond to differential stimuli.

【 授权许可】

Unknown