Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice

FEBS Letters

Emilsson, Valur¹  Cawthorne, Michael A.¹  Liu, Yong-Ling¹ 

[1] Clore Laboratory, University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK

关键词: Leptin;    Leptin receptor;    Skeletal muscle;    Glycogen synthesis;    Insulin;    ob/ob mouse;   

DOI  :  10.1016/S0014-5793(97)00732-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ob gene product, leptin, causes significant and dose-dependent inhibition of basal and insulin-stimulated glycogen synthesis in isolated soleus muscle from ob/ob mice, and a smaller, non-significant inhibition in muscle from wild-type mice. Leptin had no inhibitory effect on glycogen synthesis in soleus muscle from the diabetic (db/db) mice, which lack the functional leptin receptor. The full-length leptin receptor (Ob-Rb), is expressed in soleus muscle of both ob/ob and wild-type mice, however with no detectable differences in expression level. These results suggest that hyperleptinaemia may attenuate insulin action on glucose storage in skeletal muscle.

【 授权许可】

Unknown