FEBS Letters | |
Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice | |
Emilsson, Valur1  Cawthorne, Michael A.1  Liu, Yong-Ling1  | |
[1] Clore Laboratory, University of Buckingham, Hunter Street, Buckingham MK18 1EG, UK | |
关键词: Leptin; Leptin receptor; Skeletal muscle; Glycogen synthesis; Insulin; ob/ob mouse; | |
DOI : 10.1016/S0014-5793(97)00732-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The ob gene product, leptin, causes significant and dose-dependent inhibition of basal and insulin-stimulated glycogen synthesis in isolated soleus muscle from ob/ob mice, and a smaller, non-significant inhibition in muscle from wild-type mice. Leptin had no inhibitory effect on glycogen synthesis in soleus muscle from the diabetic (db/db) mice, which lack the functional leptin receptor. The full-length leptin receptor (Ob-Rb), is expressed in soleus muscle of both ob/ob and wild-type mice, however with no detectable differences in expression level. These results suggest that hyperleptinaemia may attenuate insulin action on glucose storage in skeletal muscle.
【 授权许可】
Unknown
【 预 览 】
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RO201912020304613ZK.pdf | 621KB | download |