Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell‐cycle machinery

FEBS Letters

Bernards, René¹  Peeper, Daniel S¹ 

[1] The Netherlands Cancer Institute, Division of Molecular Carcinogenesis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

关键词: Signal transduction;    Cell cycle;    Ras;    Rb;   

DOI  :  10.1016/S0014-5793(97)00319-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the past decade, we have gained considerable insight into the identities of various cytoplasmic signal transduction cascades and the manner in which they operate in response to changes in the extracellular environment. Moreover, we have begun to understand what the key players are in cell-cycle regulation and how they, in turn, function to promote cell division. A long-standing question, however, has been how communication between signalling routes and the cell-cycle machinery occurs. This review highlights some recent observations that provide possible links between signal transduction and the cell-cycle machinery.

【 授权许可】

Unknown