FEBS Letters | |
In search of a function for the TIS21/PC3/BTG1/TOB family | |
Magaud, Jean-Pierre1  Berthet, Cyril1  Rouault, Jean-Pierre1  Matsuda, Satoru2  | |
[1] Unité INSERM U453 affiliée au CNRS, Centre Léon Bérard, 28 rue Laennec, F-69373 Lyon Cedex 08, France;Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan | |
关键词: Btg1; Btg2; Btg3; Tob; Tob2; Pc3; Pc3b; Pc3k; Tis21; Fog3; Amphitob; Ana; B9-10; B9-15; Cell cycle; p53; Rb; Anti-proliferative activity; | |
DOI : 10.1016/S0014-5793(01)02436-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The Btg family of anti-proliferative gene products includes Pc3/Tis21/Btg2, Btg1, Tob, Tob2, Ana/Btg3, Pc3k and others. These proteins are characterized by similarities in their amino-terminal region: the Btg1 homology domain. However, the pleiotropic nature of these family proteins has been observed and no common physiological function among family members was suggested from the history of their identification. Recent progress in the search for Btg family functions has come from the analysis of cell regulation and of cell differentiation. It is now emerging that every member of this family has a potential to regulate cell growth. We would like to propose here to use a nomenclature APRO as a new term for the family.
【 授权许可】
Unknown
【 预 览 】
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