Coexistence of somatostatin receptor subtypes in the human neuroblastoma cell line LA‐N‐2

FEBS Letters

Folkesson, Ronnie¹  Nilsson, Lars¹ 

[1] Department of Clinical Neuroscience and Family Medicine, Division of Geriatric Medicine, Alzheimer's Disease Research Center, Karolinska Institute, Huddinge University Hospital B84, S-141 86 Huddinge, Sweden

关键词: Somatostatin;    Neuroblastoma;    Human;    LA-N-2;    Coexistence;    Receptor;    Subtype;   

DOI  :  10.1016/S0014-5793(96)01441-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Five distinct human somatostatin receptor subtypes have recently been cloned and characterized. Previous studies have suggested that these receptor subtypes might display coexistent localization, based on in situ hybridization or immunoblockage experiments. Here we provide evidence for coexistence of somatostatin receptor subtypes 2 and 5 in the human neuroblastoma cell line LA-N-2, using a combined approach with RT-PCR and receptor binding studies with somatostatin analogues. Somatostatin receptor subtypes simultaneously localized to a single cell might serve distinct functions in terms of targeting to different intraneuronal compartments or subtype specificity against so far unidentified somatostatin-related peptides.

【 授权许可】

Unknown