Protein‐mediated protein maturation in eukaryotes

FEBS Letters

Haas, Ingrid G.¹ 

[1] Institut für Biochemie I, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany

关键词: Heat shock protein;    Intracellular compartment;    Intracellular protein targeting;    Folding;    in vivo;    Molecular chaperone;   

DOI  :  10.1016/0014-5793(95)00619-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Eukaryotic cells have developed particular strategies to support the critical steps in protein maturation that starts in the cytosol with the birth of a nascent polypeptide chain, and ends when the protein has reached the appropriate compartment and/ or has attained its mature structure. Many of the cellular proteins that have evolved to promote maturation processes are constitutively expressed members of the highly conserved heat shock protein (hsp) family, also known as “molecular chaperones”. Protein-mediated processes that occur in the cytosol are discussed.

【 授权许可】

Unknown