Tuftsin‐bearing liposomes as drug vehicles in the treatment of experimental aspergillosis

FEBS Letters

Jaina, R.K.¹  Gupta, C.M.¹  Owais, Mohd.¹  Bachhawat, B.K.²  Ahmed, I.²  Krishnakumar, B.¹ 

[1] Institute of Microbial Technology, Chandigarh-160014, India;Liposome Research Centre, Delhi University South Campus, Benito Juarej Road, New Delhi-110021, India

关键词: Tuftsin;    Macrophage activation;    Fungal infection;    Liposome;    Amphotericin B;   

DOI  :  10.1016/0014-5793(93)81760-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Encapsulation of amphotericin B in tuftsin-bearing liposomes greatly increased its efficacy in treatment of human aspergillosis in mice. Also, the drug efficacy was significantly increased by pretreating the animals with drug-free tuftsin-bearing liposomes. These results demonstrate that macrophage activation can considerably enhance the therapeutic efficacy of antifungal drugs, like amphotericin B.

【 授权许可】

Unknown