The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity

FEBS Letters

Jaffrézou, Jean-Pierre²  Laurent, Guy¹ 

[1]Department of Hematology, Centre Hospitalier Universitaire Purpan, Toulouse 31059, France

[2]Department of Medicine, Division of Oncology and Clinical Pharmacology, R-M211, Stanford University Medical Center, Stanford, CA 94305-5306, USA

关键词: Immunotoxin;    Multidrug resistance;    P-Glycoprotein;    Drug trafficking;    Lipid metabolism;    Chemosensitizer;   

DOI  :  10.1016/0014-5793(93)81337-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand-toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.

【 授权许可】

Unknown