Heat shock increases turnover of 90 kDa heat shock protein phosphate groups in HeLa cells

FEBS Letters

Legagneux, Vincent¹  Bensaude, Olivier¹  Morange, Michel¹ 

[1] Laboratoire de Biologie Moléculaire du Stress, Département de Biologie, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris Cedex 05, France

关键词: Heat shock;    Heat shock protein;    Protein phosphorylation;    HeLa cell;   

DOI  :  10.1016/0014-5793(91)81320-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The 90 kDa heat shock protein (hsp9O) is a major phosphoprotein which associates various other cellular polypeptides such as actin, calmodulin, steroid hormone receptors and certain protein-kinases. Little is known about the function of hsp9O in recovery from stress. In this report, we describe a dramatic increase in the rate of both phosphate uptake and dephosphorylation of hsp9O in HeLa cells submitted to acute stresses. This increased turnover of hsp9O phosphate groups might reflect a greater protein binding activity of hsp9O in stressed cells.

【 授权许可】

Unknown