期刊论文详细信息
FEBS Letters | |
Phosphorylation of the 90 kDa heat shock protein in heat shocked HeLa cell lysates | |
Legagneux, Vincent2  Dubois, Marie-Françoise1  Bensaude, Olivier2  Morange, Michel2  | |
[1] INSERM U.43 Hôpital St Vincent de Paul, 74, av. Denfert-Rochereau, 75014 Paris, France;Groupe de Biologie Moléculaire du Stress, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15 France | |
关键词: Heat shock; Heat shock protein; Protein phosphorylation; Eukaryotic initiation factor; Protein kinase; (HeLa cell); | |
DOI : 10.1016/0014-5793(88)80862-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The 90 kDa heat shock protein (hsp 90) is a major phosphorylated protein under normal growth conditions. However, it does not incorporate detectable levels of phosphate by incubation of control HeLa cell lysates with [γ-32P]ATP in vitro. In this paper we show that strong phosphorylation of hsp 90 occurs in lysates prepared from heat shocked HeLa cells. Possible involvement of the eukaryotic initiation factor 2 kinase of the heme-controlled repressor of translation is discussed.
【 授权许可】
Unknown
【 预 览 】
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