Both D factor/LIF and IL‐6 inhibit the differentation of mouse teratocarcinoma F9 cells

FEBS Letters

Tomida, Mikio²  Nagata, Kazuhiro¹  Yamamoto-Yamaguchi, Yuri²  Tsuru, Akio¹  Goeddel, D.V.⁴  Yamashita, Michiaki¹  Hozumi, Motoo²  Hirayoshi, Kazunori¹  Yasukawa, Kiyoshi³ 

[1] Department of Cel Biology, Chest Disease Research Institute, University of Kyoto, Kyoto 606, Japan;Department of Chemotheraphy, Saitama Cancer Research Institute, Saitama 362, Japan;Tokyo Research Center, Tosah Corp., Kanogawa 252, Japan;Department of Molecular Biology, Genentech Inc., South San Francisco, CA 894080, USA

关键词: Differentiation factor;    Leukemia inhibitory factor;    IL-6;    Differentiation;    F9 cell;   

DOI  :  10.1016/0014-5793(91)80523-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Differentation-stimulating factor (D factor)/leukemia inhibitory factor (LIF) and IL-6 are reported to be cytokines having multifaced functions including the induction of differentation in mouse myeloid leukemia MI cells. We here report that both D factor/LIF and IL-6 inhibit the differentation of mouse teratocarcinoma F9 cells induced by retinoic acid alone or combined with dibutyryl cAMP. From the microscopic observation as well as Northern blot analysis using cDNA probes encoding several marker proteins for differentiation of F9 cells, we conclude that D factor/ LIF and IL-6 are functionaly closely related in the induction of differentation in MI cells in the inhibition of F9 differentiation.

【 授权许可】

Unknown