In‐vitro matured human macrophages express Alzheimer's βA4‐amyloid precursor protein indicating synthesis in microglial cells

FEBS Letters

Ganter, Ursula²  Weidemann, Andreas¹  Mönning, Ursula¹  Bauer, Joachim²  Beyreuther, Konrad¹  Strauss, Sylvia³  Jonas, Uwe¹  Masters, Colin L.⁴  Volk, Benedikt³  König, Gerhard¹  Berger, Mathias² 

[1] Zentrum für Molekulare Biologie, Im Neuenheimer Feld 282, D-6900 Heidelberg, Germany;Psychiatrische Universitätsklinik, Universität Freiburg, Hauptstrasse 5, D-7800 Freiburg, Germany;Abteilung Neuropathologie, Universität Freiburg, D-7800 Freiburg, Germany;Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia

关键词: Macrophage;    Microglia;    Amyloid precursor protein;    Alzheimer's disease;   

DOI  :  10.1016/0014-5793(91)80508-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Microglia which are consistently associated with Alzheimer's disease (AD) senile plaques are part of the mononuclear phagocyte system. In-vitro matured human monocyte-derived macrophages feature many immunological characteristics of microglia. We found strong constitutive expression of Alheimer's βA4-amyloid precursor protein (APP) in human mononuclear phagocytes after terminal in-vitro maturation from monocytes to macrophages. Amyloid has previously been found to be associated with microglia in AD brains, however, it remained unclear whether the material was synthesized in or had been phagocytosed by the cells. The findings presented here support the assumption that brain microglia may contribute to APP synthesis in AD brain.

【 授权许可】

Unknown