Synthesis and secretion of Alzheimer amyloid βA4 precursor protein by stimulated human peripheral blood leucocytes

FEBS Letters

Mönning, Ursula¹  Mechler, Hans¹  Schreiter-Gasser, Ursula³  Beyreuther, Konrad¹  Masters, Colin L.²  König, Gerhard¹  Prior, Reinhard¹ 

[1] Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, D-6900 Heidelberg, Germany;Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia;Central Institute for Mental Health, J 5, D-6800 Mannheim, Germany

关键词: Alzheimer's disease;    Amyloid precursor protein;    Leucocyte;   

DOI  :  10.1016/0014-5793(90)80861-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.

【 授权许可】

Unknown