In vitro transcription of the mouse whey acidic protein promoter is affected by upstream sequences

FEBS Letters

Lubon, Henryk¹  Pittius, Christoph W.¹  Hennighausen, Lothar¹ 

[1] Laboratory of Biochemistry and Metabolism, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

关键词: Transcription;    Sequence specificity;    Promoter binding;    Gene promoter;   

DOI  :  10.1016/0014-5793(89)81449-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The promoter sequences from −175 to +10 of the mouse whey acidic protein (WAP) gene are a target for sequence-specific binding of nuclear proteins [(1987) Nucleic Acids Res. 15, 2103–2121]. Using in vitro transcription assays based on nuclear extracts, transcription factors were shown to bind to these sequences and promoter upstream sequences were found to stimulate transcription.

【 授权许可】

Unknown