Calcitonin gene‐related peptide‐1 (CGRP‐1) is a potent regulator of glycogen metabolism in rat skeletal muscle

FEBS Letters

Foot, Elizabeth A.¹  Leighton, Brendan¹  King, Jayne M.¹  Cooper, Garth G.J.S.² 

[1] Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England;Medical Research Council Immunochemistry Unit, University of Oxford, South Parks Road, Oxford OX1 3QU, England

关键词: Amylin;    Insulin resistance;    Diabetes mellitus;   

DOI  :  10.1016/0014-5793(89)80658-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We investigated the effects of CGRP on glucose metabolism in intact rat skeletal muscle preparations that are largely composed of either type I (soleus) or II fibres (e.g. extensor digitorum longus (EDL) or epitrochlearis muscles). CGRP-1 inhibited insulin-stimulated glycogen synthesis in both soleus and EDL muscle preparations. Rat CGRP-1 was a potent stimulator of glycogenolysis only in muscles composed of type II fibres, which depend on high rates of glycogenolysis to produce high power outputs. These results may provide the basis for understanding how CGRP regulate glycogenolysis in type II fibres in vivo.

【 授权许可】

Unknown