High pericardial and peri-aortic adipose tissue burden in pre-diabetic and diabetic subjects

BMC Cardiovascular Disorders

Ricardo C Cury³  Bernard E Bulwer⁶  Jason Jeun-Shenn Lee⁵  Hung-I Yeh¹  Charles Jia-Yin Hou¹  Chung-Lieh Hung¹  Jen-Yuan Kuo¹  Yih-Jer Wu¹  Chuan-Chuan Liu⁸  Hiram G Bezerra⁴  Ya-Ching Hsieh²  Tung-Hsin Wu⁵  Chun-Ho Yun⁵  Fei-Shih Yang⁷ 

[1] Department of Medicine, Mackay Medical College, and Mackay Medicine Nursing and Management College, Taipei, Taiwan;Department of Anesthesia, Peking University First Hospital, Beijing, China;Department of Radiology, Cardiovascular MRI and CT Program, Baptist Cardiac and Vascular Institute, Miami, FL, USA;Cardiovascular Department, University Hospitals Case Medical Center, Cleveland, USA;Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan;Noninvasive Cardiovascular Research, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA;Department of Radiology, Mackay Memorial Hospital, Taipei, Taiwan;Department of Medical Technology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan

关键词: Insulin resistance;    Peri-aortic adipose tissue;    Pericardial adipose tissue;    MDCT;    Diabetes mellitus;    Pre-diabetes;   

Others  :  856701
DOI  :  10.1186/1471-2261-13-98

 received in 2013-08-10, accepted in 2013-10-28,  发布年份 2013

【 摘 要 】

Background

Central obesity in relation to insulin resistance is strongly linked to the development of type 2 diabetes. However, data regarding the association between pericardial and peri-aortic adiposity, a potential estimate of visceral adipose tissue burden, and pre-diabetes status remains unclear.

The aim of this study was to examine whether the degree of pericardial and thoracic peri-aortic adipose tissue, when quantified by multi-detector computed tomography (MDCT), differs significantly in a normal, pre-diabetic, and overtly diabetic population.

Methods

We studied 562 consecutive subjects including 357 healthy, 155 pre-diabetic, and 50 diabetic patients selected from participants who underwent annual health surveys in Taiwan. Pre-diabetes status was defined by impaired fasting glucose or impaired glucose intolerance according to American Diabetes Association guidelines. Pericardial (PCF) and thoracic peri-aortic (TAT) adipose tissue burden was assessed using a non-contrast 16-slice multi-detector computed tomography (MDCT) dataset with off-line measurement (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Body fat composition, serum high-sensitivity C-reactive protein (hs-CRP) level and insulin resistance (HOMA-IR) were also assessed.

Results

Patients with diabetes and pre-diabetes had greater volume of PCF (89 ± 24.6, 85.3 ± 28.7 & 67.6 ± 26.7 ml, p < 0.001) as well as larger TAT (9.6 ± 3.1 ml vs 8.8 ± 4.2 & 6.6 ± 3.5 ml, respectively, p < 0.001) when compared to the normal group, although there were no significant differences in adiposity between the diabetic and pre-diabetic groups. For those without established diabetes in our study, increasing TAT burden, but not PCF, appear to correlate with insulin resistance (HOMA-IR) and hs-CRP in the multivariable models.

Conclusions

Pre-diabetic and diabetic subjects, compared to normoglycemia, were associated with significantly higher pericardial and peri-aortic adipose tissue burden. In addition, visceral fat accumulation adjacent to the thoracic aorta seemed to exert a significant impact on insulin resistance and systemic inflammation.

【 授权许可】

   
2013 Yang et al.; licensee BioMed Central Ltd.

【 图 表 】

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