Antidiabetic Activity of Self Nanoemulsifying Drug Delivery System from Bay Leaves (Eugenia polyantha Wight) Ethyl Acetate Fraction

International Conference on Advanced Materials for Better Future 2016

Prihapsara, F.^1 ; Harini, M.^2 ; Widiyani, T.^2 ; Artanti, A.N.^1 ; Ani, I.L.^2

Department of Pharmacy, Faculty of Mathematics and Natural Science, Sebelas Maret University, Indonesia^1

Department of Biology, Faculty of Mathematics and Natural Science, Sebelas Maret University, Indonesia^2

关键词: Antidiabetic activity;    Drug delivery system;    Insulin resistance;    Morphological observations;    Nanoemulsion particles;    Self nanoemulsifying drug delivery system (SNEDDS);    Target tissues;    Virgin coconut oil;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/176/1/012004/pdf
DOI  :  10.1088/1757-899X/176/1/012004

来源: IOP

【 摘 要 】

Insulin resistance is caused by inability of target tissues to insulin response. Bay leaves (Eugenia polyantha Wight) fraction or extract have been used for the treatment of antidibetic mellitus type-2 resistance insulin (ADMRI) but it has low solubility and bioavailability. To overcome these problems, ethyl acetate fraction of bay leaves was formulated into self nanoemulsifying drug delivery system (SNEDDS) using Virgin Coconut Oil (VCO) as a carrier oil. This study aims to produce nanoherbal medicine, determine effect of nanoherbal preparation derived from bay leaves as an anti-ADMRI. The results showed that the optimum SNEDDS formula was tween 80 : PEG 400 : Virgin Coconut Oil (30% : 60% : 10%) in 5 mL. It has emulsification time 13.00 seconds with the average of droplet size value 84.5 nanometer and zeta potential value ± 0.2 mV. Morphological observation showed the nanoemulsion particles has spherical shaped and stable in different pH media. Hypoglycaemic effect of single dose metformin, SNEDDS, combination a-half dose of SNEEDS with metformin value is 28.3%; 15.6%; 34.6% respectively.