S15261 antagonises amylin‐induced impaired glucose tolerance

FEBS Letters

Duhault, J.¹  Espinal, J.¹  Berger, S.¹  Lacour, F.¹ 

[1] Division des Maladies Métaboliques, Institut de Recherches Servier, 11, rue des Moulineaux, 92150 Suresnes, France

关键词: Amylin;    Insulin resistance;    Diabetes;    S15261;    Portal vein;   

DOI  :  10.1016/0014-5793(95)00592-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Amylin has been postulated to antagonise or inhibit the action of insulin in peripheral rat tissues and thus contribute to, or be responsible for, the development of insulin resistance. We have recently reported that S15261 is a compound capable of increasing insulin sensitivity in ageing insulin resistant rats. In order to assess whether S15261 had any effects on amylin induced insulin resistance we used a model where amylin causes an impairement in glucose tolerance in an acute manner, by means of an intraportal infusion of the hormone in normal rats. We report here that S15261 can antagonise this amylin-induced impaired glucose tolerance.

【 授权许可】

Unknown