A growth factor for hepatocytes is inactivated by sub‐lethal γ‐irradiation in vivo or in vitro

FEBS Letters

Ord, Margery G.¹  Skouteris, George G.¹  Stocken, Lloyd A.¹ 

[1] Department of Biochemistry, South Parks Road, Oxford OX1 3QU, England

关键词: Liver growth factor;    Prostaglandin E2;    Liver regeneration;    Ionizing irradiation;   

DOI  :  10.1016/0014-5793(89)80211-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Serum from partially hepatectomised rats promoted DNA synthesis in primary adult rat hepatocyte cultures. If the rats had been exposed to sub-lethal γ-irradiation immediately following operation or if their serum, collected at 3 h, was exposed to irradiation in vitro, the growth-promoting activity was destroyed. Prostaglandin E₂ also stimulated DNA synthesis in the cultures; if PGE₂ was irradiated in serum from intact or partially hepatectomised rats its growth-promoting activity was markedly diminished.

【 授权许可】

Unknown