Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells

FEBS Letters

Ando, Akio²  Ueda, Naohiko³  Kamada, Takenobu³  Fujiwara, Yoshihiro¹  Yokoyama, Kenji³  Ochi, Satoshi³  Fujibayashi, Mari²  Hirano, Toshio²  Fukunaga, Megumu³ 

[1] Division of Oncology, Biomedical Research Center, Osaka University Medical School, Osaka, Japan;Medical Science of Health, Second Division, Osaka University, Osaka, Japan;First Department of Medicine, Osaka University Medical School, Osaka, Japan

关键词: Interleukin 6;    Mesangial cell;    Signal transduction mechanism;    Phosphoinositide turnover;    Intracellular calcium;    Prostaglandin E2;   

DOI  :  10.1016/0014-5793(91)80813-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interleukin 6 (IL-6) is one of the potent autocrine growth factors for mesangial cells. We investigated the signal transduction mechanism or IL-6 in cultured rat mesangial cells. IL-6 induced a transient increase of inositol 1,4,5-trisphosphate (Ins 1,4,5-P₃) followed by a transient and sustained increase of intracellular calcium concentration, suggesting that IL-6 stimulates phosphoinositide turnover. IL-6 also stimulated prostaglandin E₂ (PGE₂) production. The IL-6-concentration dependency in PGE₂ production was similar to that in Ins 1,4,5-P₃ production. We concluded that the action of IL-6 on mesangial cells is exerted at least partially through the enhancement of phosphoinositide turnover and PGE₂ production.

【 授权许可】

Unknown