Identification and signal transduction mechanism of elastin peptide receptor in human leukocytes

FEBS Letters

Robert, L.¹  Fülöp, T.²  Jacob, M.P.¹  Varga, Z.² 

[1] Laboratoire de Biochimie du Tissu Conjonctif(UA CNRS 1174), Faculté de Médecine, Créteil, France;First Department of Medicine, Univ. Med. School, POB 19, Debrecen, H-4012 Hungary

关键词: Elastin peptide;    Signal transduction mechanism;    Phosphatidylinositol breakdown;   

DOI  :  10.1016/0014-5793(89)81602-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The existence of a novel receptor on human polymorphonuclear leukocytes (PMNLs) and monocytes was demonstrated, named soluble elastin peptide receptor. Soluble elastin peptides, like K-elastin, which are liberated from elastin fibres, can be found in the sera, and they possess several biological activities such as chemotaxis. Studying the effects of elastin peptides on leukocytes, it was found that: (i) the elastin peptide stimulates the oxidative burst, the intracellular free Ca²⁺ elevation through a specific receptor; and (ii) in the signal transduction mechanism of this elastin peptide receptor, the phosphatidylinositol breakdown is involved.

【 授权许可】

Unknown