Effects of a Mediterranean Diet on the Prostaglandin E2 Pathway in Individuals at High Risk for Colon Cancer.

Prostaglandin E2;Mediterranean dietary intervention;subjects at increased risk of colon cancer;Public Health;Health Sciences;Environmental Health Sciences

Sidahmed, ElkhansaSen, Ananda ;

University of Michigan

关键词: Prostaglandin E2;    Mediterranean dietary intervention;    subjects at increased risk of colon cancer;    Public Health;    Health Sciences;    Environmental Health Sciences;   

Others  :  https://deepblue.lib.umich.edu/bitstream/handle/2027.42/113482/sidahmed_1.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Prostaglandin E2 (PGE2) is a pro-inflammatory mediator in the colon, and high levels of PGE2 increase the risk of colon cancer. PGE2 production can be inhibited by the use of non-steroidal anti-inflammatory drugs, but these agents have unacceptable side effects for long-term use in a cancer prevention setting. Dietary approaches for prevention therefore are an attractive, non-toxic alternative. In particular, the Mediterranean diet may be ideal, and it appears to have preventive and anti-inflammatory effects. The central hypothesis of this thesis research was that adherence to a Mediterranean dietary intervention would favorably affect the expression of the enzymes that degrade and synthesize PGE2. The study recruited 120 subjects at increased risk of colon cancer, and they were randomized to a Mediterranean or a Healthy Eating diet. Dietary data, blood and colon tissue biopsies were collected at baseline and after six months. At baseline, there were strong, positive, associations of colon PGE2 concentrations with cyclooxgenase-1 expression and with saturated fatty acid concentrations in the colon biopsies. Study subjects showed excellent adherence to the dietary interventions. This was reflected in serum nutrient biomarkers but change in colon tissue nutrient biomarkers was modest. Surprisingly, the Mediterranean diet intervention showed no significant effects on colon PGE2, but a prostaglandin formed from omega-3 fatty acids, PGE3, was increased in the Mediterranean arm, as was cytoplasmic prostaglandin E synthase 3. This indicates that dietary intervention in healthy persons may work to increase preventive compounds such as PGE3 without affecting PGE2. In addition, the results indicated that cyclooxygenase (COX)-1, and not the inducible COX-2, was a major determinant of colon PGE2.Since neither of the interventions changed COX-1 expression nor saturated fatty acid concentrations in the colon, further research should investigate the biological factors that contribute to inter-individual variability in these two significant determinants of colonic PGE2.nor saturated fatty acid concentrations in the colon, further research should investigate the biological factors that contribute to inter-individual variability in these two significant determinants of colonic PGE2.