FEBS Letters | |
Inhibition of myeloid differentiation by inhibitors of ADP‐ribosylation | |
Wu, Fu-Mei1  Zaun, M.Rebecca1  Wu, Ming-chi1  | |
[1] Department of Biochemistry, Texas College of Osteopathic Medicine, University of North Texas, Denton, TX 76203, USA | |
关键词: Leukemia; Cell differentiation; Colony-stimulating factor; ADP-ribosylation; BADGH; benzylaminododecylguanidine hydrochloride; MBAMG; p-methoxylbenzylaminodecamethylene guanidine sulfate; GM-CSF; granulocyte-macrophage colony-stimulating factor; G-CSF; granulocyte colony-stimulating factor; DME-S; Dulbecco's modified Eagle's with serum; CSF; colony-stimulating factor; E-MLCM; endotoxin-treated mouse lung conditioned medium; | |
DOI : 10.1016/0014-5793(89)80558-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Inhibitors of ADP-ribosylation inhibited the myeloid differentiation of murine myelomonocytic leukemia WEHI-3BD+ cells induced by granulocyte colony-stimulating factor. Benzamide, at 2.0 mM, inhibited 50% of the WEHI-3BD+ cell differentiation but had no significant effect on the proliferation. However, benzylaminododecylguanine hydrochloride and p-methoxylbenzylaminodecamethylene guanidine sulfate at 2.0 and 2.2 μM, respectively, inhibited 50% of proliferation but had no effect at all on differentiation. The differential effects of inhibitors provide a model to study the role of ADP-ribosylation in myeloid differentiation.
【 授权许可】
Unknown
【 预 览 】
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