Dexamethasone‐induced reduction of phospholipase D activity in the rat Possible role of lipocortin

FEBS Letters

Kobayashi, Mutsuhiro¹  Singh, Indrapal¹  Bansal, Vinay S.¹  Kanfer, Julian N.¹ 

[1] Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg R3E 0 W3, Canada

关键词: Phospholipase D;    Lipocortin;    Dexamethasone;   

DOI  :  10.1016/0014-5793(88)80060-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Subcutaneous injection of dexamethasone resulted in a reduction of demonstrable phospholipase D activity of rat brain and liver microsomes. Partially purified rat lung lipocortin inhibited the activity of both microsomal and partially purified rat brain phospholipase D. These results show that phospholipase D activity is suppressed by dexamethasone and one of the possible mechanisms of inhibition may be a phospholipase inhibitory protein, lipocortin.

【 授权许可】

Unknown