Development of 7,3’,4’-Trihydroxyisoflavone, an Enzyme-Converted Soy Isoflavone of Daidzein, as Anti-Atopic Cosmetic Material

Soybean;Isoflavone;Daidzein;7;3’;4’-trihydroxyisoflavone;Dexamethasone;Atopic dermatitis;NC/Nga;DFE;Enzyme Conversion;Physicochemical stability;Cosmetic material;Topical application;TARC(CCL17);MDC(CCL22);IgE;630

농업생명과학대학 농생명공학부 ;

University:서울대학교 대학원

关键词: Soybean;    Isoflavone;    Daidzein;    7;    3’;    4’-trihydroxyisoflavone;    Dexamethasone;    Atopic dermatitis;    NC/Nga;    DFE;    Enzyme Conversion;    Physicochemical stability;    Cosmetic material;    Topical application;    TARC(CCL17);    MDC(CCL22);    IgE;    630;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/137571/1/000000145368.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

thymus and activation regulated chemokine (TARC/CCL17), Macrophage-Derived Chemokine(MDC/CCL22) in HaCaT cell line. And we confirmed that the anti-atopic effect is also available in cosmetic formulation in NC/Nga mice model induced by Dermatophagoides-farina extract(DFE). Histological analysis demonstrated that 7,3’,4’-THIF decreased DFE-induced eosinophil and mast cell infiltration into skin lesions. We also found that 7,3’,4’-THIF significantly reduced the DFE-induced increase in serum IgE and MDC level. We confirmed the liver and kidney toxicity compared to dexamethasone. These results suggest that 7,3’,4’-THIF might be a cosmeceutical material candidate for the treatment of AD.