Nitrofuran inhibition of microsomal lipid peroxidation

FEBS Letters

Dubin, M.¹  Grinblat, L.¹  Stoppani, A.O.M.¹  Villamil, S.H.Fernandez¹ 

[1] Centro de Investigaciones Bioenergéticas, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina

关键词: Microsome;    Lipid peroxidation;    Nitro compound;    Nifurtimox;    (Liver);    nifurtimox;    3-methyl-4-(5′-nitrofurfurylideneamino)tetrahydro-4H-thiazone-1-1′-dioxide;    benznidazole;    N-benzyl-2-nitro-1-imidazole acetamide;    MDA;    malondialdehyde;    DMFA;    dimethylformamide;    t-BuOOH;    tert-butyl hydroperoxide;    G-6-P;    glucose 6-phosphate;   

DOI  :  10.1016/0014-5793(87)80902-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two nitrofuran compounds, nifurtimox and nitrofurantoin, inhibited in a concentration-dependent manner the NADPH-, iron-induced lipid peroxidation in rat liver microsomes, as shown by the decreased rate of MDA accumulation. Other nitro compounds (benznidazole and chloramphenicol) were relatively inactive. Nifurtimox inhibition affected polyenoic fatty acids and cytochrome P-450 degradation that follows lipid peroxidation. The ascorbate- or tert-butyl hydroperoxide-dependent lipid peroxidations were much less inhibited than the NADPH-dependent one. Nifurtimox and nitrofurantoin, but not benznidazole and chloramphenicol, strongly stimulated the microsomal NADPH-oxidase activity, thus supporting electron diversion, as the main cause of the inhibition of peroxidation initiation.

【 授权许可】

Unknown