Antioxidant effect of caeruloplasmin on microsomal lipid peroxidation

FEBS Letters

Kajimoto, Goro¹  Yamashoji, Shiro¹ 

[1] Faculty of Nutrition, Kobe-Gakuin University, Kobe 673, Japan

关键词: Lipid peroxidation;    Antioxidant effect;    Caeruloplasmin;    Microsome;   

DOI  :  10.1016/0014-5793(83)80371-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Microsomal NADPH-dependent lipid peroxidation catalyzed by ADP-Fe³⁺ was inhibited by the addition of caeruloplasmin. The antioxidant effect of caeruloplasmin was independent of the superoxide anion (O⁻ ₂ scavenging activity. Since caeruloplasmin enhanced the function of ADP-Fe³⁺ acting as electron acceptor for microsomal electron transport system, the antioxidant effect of caeruloplasmin is considered to depend on the ferroxidase activity.

【 授权许可】

Unknown