Antioxidant properties of caeruloplasmin towards iron‐ and copper‐dependent oxygen radical formation

FEBS Letters

Gutteridge, John M.C.¹ 

[1] Division of Antibiotics, National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB, England

关键词: Caeruloplasmin;    Antioxidant;    Lipid peroxidation;    Hydroxyl radical;    Ferroxidase;    Metal ion-dependent free radical;   

DOI  :  10.1016/0014-5793(83)81111-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The antioxidant activity of caeruloplasmin can be mainly ascribed to its ferroxidase activity which effectively inhibits ferrous ion-stimulated lipid peroxidation and ferrous ion-dependent formation of hydroxyl radicals in the Fenton reaction. In addition, caeruloplasmin can prevent copper ions from stimulating lipid peroxidation.

【 授权许可】

Unknown