NO•, CO and •OH Endogenous soluble guanylyl cyclase‐activating factors

FEBS Letters

Schmidt, Harald H.H.W.¹ 

[1] Northwestern University Medical School, Department of Pharmacology, Chicago, IL 60611, USA

关键词: l-Arginine;    Heme oxygenase;    Carbon monoxide;    Lipid peroxidation;    Xanthine oxidase;    Hydroxyl radical;    Cyclic GMP;    biopterin;    6-(l-erythro-1′;    2′-dihydroxyprop yl)-pterin;    cGMP;    cyclic guanosine 3′;    5′-monophosphate;    CPR;    NADPH-cytochrome P450 raductase;    GAF;    soluble guanylyl cyclase-activating-factor;    GC-S;    soluble guanylyl cyclase;    H2biopterin;    (6R)-7;    9-dihydrobiopterin;    H4biopterin;    (6R)-5;    6;    7;    8-tetrahydrobiopterin;    LPO;    lipid peroxidation;    NO;    nitric oxide;    NOS;    NO synthase;    OH;    hydroxyl radical;    q-H2biopterin;    (6R)-6;    7-dibydroblopterin;    XOD;    xanthine oxidase;   

DOI  :  10.1016/0014-5793(92)80910-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these are formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3′, 5′-monophosphate level.

【 授权许可】

Unknown