Isolation and characterization of variant IGF‐1 as well as IGF‐2 from adult human brain

FEBS Letters

Andersson, Charlotte¹  Bergman, Tomas²  Sara, Vicki R.¹  Holmgren, Arne²  Lundquist, Gunilla²  Sjögren, Barbro¹  Carlsson-Skwirut, Christine¹  Jörnvall, Hans² 

[1] Karolinska Institute's Depannent of Psychiatry, St. Göran's Hospital, Box 12500, 112 81 StockholmSweden;Department of Chemistry I, Karolinska Institute, 104 01 Stockholm, Sweden

关键词: Somatomedin;    Insulin-like growth factor 1;    Insulin-like growth factor 2;    Amino acid sequence;    Central nervous system;    Neuropeptide;   

DOI  :  10.1016/0014-5793(86)80568-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The forms of somatomedin present in the adult human brain have been characterized in this study. Two peptides were purified by acidification, size exclusion chromatography, affinity chromatography, FPLC and HPLC. structural analysis identified these peptides as the variant form of IGF-1 with a truncated N-terminal region earlier isolated from human fetal brain and IGF-2. The presence of the truncated IGF-1 variant and IGF-2 in the human CNS suggests their role as neuropeptides.

【 授权许可】

Unknown