Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

FEBS Letters

Jansen, M.¹  van Schaik, P.M.A.²  van Tol, H.²  Van den Brande, J.L.¹  Sussenbach, J.S.² 

[1] Department of Pediatrics, State University of Utrecht, Vondellaan 24, 3521 GG Utrecht, The Netherlands;Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24, 3521 GG Utrecht, The Netherlands

关键词: Somatomedin;    Insulin-like growth factor II;    Nucleotide sequence;    Amino acid sequence;    Hormone precursor cDNA cloning;   

DOI  :  10.1016/0014-5793(85)80527-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have isolated 3 cDNA clones encoding human IGF-II and a variant of IGF-II. The amino acid sequence encoded by the IGF-II cDNA is identical to the sequence previously described [(1978) FEBS Lett. 89, 283-286]. In the amino acid sequence predicted by the IGF-II variant cDNA, the Ser residue 29 in the B-domain has been replaced by an Arg-Leu-Pro-Gly sequence. The corresponding mRNAs probably arise by alternative splicing of a common RNA precursor. The IGF coding region of the cDNA inserts is flanked by sequences encoding a signal peptide and a carboxy-terminal peptide indicating that both human IGF-II and its variant are synthesized as precursors.

【 授权许可】

Unknown