FEBS Letters | |
Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant | |
Jansen, M.1  van Schaik, P.M.A.2  van Tol, H.2  Van den Brande, J.L.1  Sussenbach, J.S.2  | |
[1] Department of Pediatrics, State University of Utrecht, Vondellaan 24, 3521 GG Utrecht, The Netherlands;Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24, 3521 GG Utrecht, The Netherlands | |
关键词: Somatomedin; Insulin-like growth factor II; Nucleotide sequence; Amino acid sequence; Hormone precursor cDNA cloning; | |
DOI : 10.1016/0014-5793(85)80527-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We have isolated 3 cDNA clones encoding human IGF-II and a variant of IGF-II. The amino acid sequence encoded by the IGF-II cDNA is identical to the sequence previously described [(1978) FEBS Lett. 89, 283-286]. In the amino acid sequence predicted by the IGF-II variant cDNA, the Ser residue 29 in the B-domain has been replaced by an Arg-Leu-Pro-Gly sequence. The corresponding mRNAs probably arise by alternative splicing of a common RNA precursor. The IGF coding region of the cDNA inserts is flanked by sequences encoding a signal peptide and a carboxy-terminal peptide indicating that both human IGF-II and its variant are synthesized as precursors.
【 授权许可】
Unknown
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