The human insulin‐like growth factor II gene contains two development‐specific promoters

FEBS Letters

van Schaik, F.M.A.¹  Oosterwijk, C.¹  Jansen, M.²  van der Kammen, R.²  de Pagter-Holthuizen, P.¹  Van den Brande, J.L.²  Sussenbach, J.S.¹ 

[1] Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24A, 3521 GG Utrecht, The Netherlands;Department of Pediatrics, State University of Utrecht, Vondellaan 24A, 3521 GG Utrecht, The Netherlands

关键词: Insulin-like growth factor II;    Somatomedin;    Eukaryotic promoter;    Development;    (Human gene);   

DOI  :  10.1016/0014-5793(87)80066-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The insulin-like growth factors (IGF) play an important role in fetal and postnatal development. Recently, the nucleotide sequences of the cDNAs encoding IGF-I and IGF-II and part of the human IGF genes were reported. In this communication we describe two distinct IGF-II cDNAs isolated from a human adult liver and a human hepatoma cDNA library, respectively. Using these two cDNAs, we have established that the human IGF-II gene contains at least 7 exons. Two different IGF-II promoters have been identified, 19 kilobases (kb) apart, which are active in a development-specific manner. The promoter, active in the adult stage, is located only 1.4 kb downstream from the insulin gene.

【 授权许可】

Unknown