FEBS Letters | |
The human insulin‐like growth factor II gene contains two development‐specific promoters | |
van Schaik, F.M.A.1  Oosterwijk, C.1  Jansen, M.2  van der Kammen, R.2  de Pagter-Holthuizen, P.1  Van den Brande, J.L.2  Sussenbach, J.S.1  | |
[1] Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24A, 3521 GG Utrecht, The Netherlands;Department of Pediatrics, State University of Utrecht, Vondellaan 24A, 3521 GG Utrecht, The Netherlands | |
关键词: Insulin-like growth factor II; Somatomedin; Eukaryotic promoter; Development; (Human gene); | |
DOI : 10.1016/0014-5793(87)80066-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The insulin-like growth factors (IGF) play an important role in fetal and postnatal development. Recently, the nucleotide sequences of the cDNAs encoding IGF-I and IGF-II and part of the human IGF genes were reported. In this communication we describe two distinct IGF-II cDNAs isolated from a human adult liver and a human hepatoma cDNA library, respectively. Using these two cDNAs, we have established that the human IGF-II gene contains at least 7 exons. Two different IGF-II promoters have been identified, 19 kilobases (kb) apart, which are active in a development-specific manner. The promoter, active in the adult stage, is located only 1.4 kb downstream from the insulin gene.
【 授权许可】
Unknown
【 预 览 】
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