Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

BMC Endocrine Disorders

Hua-Pin Chang¹  Pen-Hua Su²  Shun-Fa Yang³  Shu-Li Wang⁴ 

[1] Department of Nursing, Asia University;Department of Pediatrics, Chung Shan Medical University Hospital;Institute of Medicine, Chung Shan Medical University;National Institute of Environmental Health Sciences;

关键词: Insulin-like growth factor 1;    Insulin-like growth factor 2;    Central precocious puberty;    Single nucleotide polymorphism;    Insulin-like growth factor binding protein 3;    Insulin-like growth factor receptor;   

DOI  :  10.1186/s12902-018-0271-1

来源: DOAJ

【 摘 要 】

Abstract Background Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). Methods We assessed single nucleotide polymorphisms (SNPs) in the IGF-1, IGF-2, IGF-3, IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and IGF -binding protein 3 (IGFBP-3) genes, and their association with demographics and metabolic proteins in girls with CPP. Z-scores of height, weight, and body mass index (BMI) were calculated with the WHO reference growth standards for children. Results IGF-1 serum levels of CPP group exhibited a higher correlation with bone age, z-scores of height and weight, and luteinizing hormone (LH) than those of control group, regardless of BMI adjustment. In the CPP group, height was associated with IGF-2(3580), an adenine to guanine (A/G) SNP at position + 3580. BMI in the CPP group was associated with IGF-2(3580), IGF1R, and the combinations of [IGF-2(3580) + IGF2R], and [IGF-2(3580) + IGFBP-3]. Body weight in the CPP group was associated with the combination of [IGF-2(3580) + IGFBP-3] (p = 0.024). Weight and BMI were significantly associated with the combination of [IGF-2(3580) + IGF2R + IGFBP-3] in the CPP group. These associations were not significantly associated with z-scores of weight, height, or BMI. The distribution of these genotypes, haplotypes, and allele frequencies were similar between control and CPP groups. Conclusions These known SNPs of these IGF-1 axis genes appear to play minor roles in the risk for development of CPP.

【 授权许可】

Unknown