Ionic regulation of cyclic AMP levels in Paramecium tetraurelia in vivo

FEBS Letters

Grünemund, Ruth¹  Schultz, Joachim E.¹  von Hirschhausen, Reginhard¹  Schönefeld, Ulrich¹ 

[1] Pharmazeutisches Institut der Universität, Morgenstelle 8, 7400 Tübingen, FRG

关键词: Adenylate cyclase;    Excitable membrane;    Calcium;    Cyclic AMP;    Paramecium;   

DOI  :  10.1016/0014-5793(84)80843-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

cAMP levels in Paramecium increased dose dependently after a step increase of [Ca] or [Sr] in the incubation, provided K was present. Two mM Ca or Sr tripled cAMP concentrations within 3 s and induced an increase in forward swimming speed. The increase in cAMP formation was strictly dependent on the Donnan ratio . Na, Li, or tetraethylammonium could not replace K. The data provide evidence for regulation of cAMP in Paramecium by the membrane surface charge as determined specifically by the K:Ca ratio.

【 授权许可】

Unknown