Reduction in p53 synthesis during differentiation of Friend‐erythroleukemia cells

FEBS Letters

Resnitzki, Dalia¹  -Dori, Ronit Ben¹  Kimchi, Adi¹ 

[1] Department of Virology, The Weizmann Institute of Science, Rehovot 76100, Israel

关键词: Friend cell;    Differentiation;    p53 Synthesis;    Cell cycle;    Interferon;   

DOI  :  10.1016/0014-5793(83)80792-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The process of cell differentiation in Friend-erythroleukemia cells was accompanied by 80–90% inhibition of p53 synthesis. This decrease was found to be linked to changes in cell-cycle distribution characteristics of the growth arrest program during differentiation rather than to the induction of the globin genes. The shut-off in the expression of p53 always preceded the specific arrest of cells in the G₀/G₁ phase. Interferon did not modulate down the expression of p53 if added to transformed non-induced Friend-erythroleukemia cells; however, it slightly enhanced the extent of reduction in p53 synthesis if added during cell differentiation, thus suggesting a differential effect of interferon between cells at different stages of differentiation

【 授权许可】

Unknown